Melanoma maligno: estudo epidemiológico dos casos diagnosticados em unidade de referência em dermatologia em Bauru-sp de 2007 a 2014 / Malignant melanoma: epidemiological study of cases diagnosed at a dermatological reference center in the city of Bauru, in the Brazilian southeast State of São Paulo, between 2007 and 2014

Introdução: No Brasil o melanoma maligno segue tendência mundial de aumento da incidência com redução da gravidade dos casos ao diagnóstico. Objetivo: Utilizar os critérios prognósticos do Grupo Multicêntrico e Multidisciplinar Brasileiro para Estudo do Melanoma aliados a características clínicas para elaborar um perfil clínico e histopatológico dos casos de melanoma. Métodos: Trata-se de estudo transversal e descritivo com análise retrospectiva de prontuários dos pacientes diagnosticados com melanoma em unidade terciária de referência em dermatologia na cidade de Bauru (SP) entre janeiro de 2007 e julho de 2014. Resultados: O sexo feminino correspondeu a 56,2%, a idade variou de 27 a 95 anos com média de 61,4 anos, e em 36% dos casos a lesão foi detectada no exame físico. A maior incidência de acometimento foi nos membros inferiores (23,5%), e o tipo extensivo superficial correspondeu a 79,6% das biópsias. A espessura média do Breslow foi de 2,9mm, e em 28,1% dos casos a lesão era in situ. Conclusões: Delineou-se o seguinte perfil: mulheres, 61 anos, com lesões localizadas em membros inferiores, subtipo extensivo superficial e com indícios de bom prognóstico. Estudos como este adquirem importância por fornecer subsídios para o delineamento de estratégias de abordagens populacionais.

Introduction: The trends of malignant melanoma in Brazil are aligned with those worldwide: increasing incidence with reduced degree of severity at diagnosis. Objective: To use the prognostic criteria of the Grupo Multicêntrico e Multidisciplinar Brasileiro para Estudo do Melanoma (Brazilian Multicenter and Multidisciplinary Group for the Study of Melanoma) combined with clinical characteristics aimed at developing a clinical and histopathological profile of melanoma cases. Methods: A cross-sectional descriptive study was carried out, with the retrospective analysis of medical records of patients diagnosed with melanoma at a tertiary dermatology reference unit in the city of Bauru, in the Brazilian southeast State of São Paulo, between January 2007 and July 2014. Results: Female patients accounted for 56.2%, with ages ranging from 27 to 95 years (Mean = 61.4 years), with a lesion having been detected on physical examination in 36% of cases. The highest incidence of the disease was in the lower limbs (23.5%), with the superficial spreading subtype corresponding to 79.6% of biopsies. The average Breslow thickness was 2.9 mm, and in 28.1% of cases, the lesion was in situ. Conclusions: The following profile emerged: women, 61-years-old, with lesions in the lower limbs, superficial spreading subtype and with evidence of good prognostic. Studies like this are important due to the fact they provide subsidies for the design of strategies to treat the population.

Quality of life profile and correlated factors in chronic leg ulcer patients in the mid-west of São Paulo State, Brazil.

BACKGROUND: Chronic leg ulcer may have an impact on patients' quality of life. OBJECTIVES: This study aimed to identify the impact of leg ulcers on patient's quality of life using the Dermatology Life Quality Index and to define the main factors correlated with this perception. METHOD: Cross-sectional, non-probabilistic sampling study. We included patients with chronic leg ulcers being treated for at least 3 months. A sociodemographic and clinical survey was conducted to assess the profile of the ulcers. We administered a screening for depressive symptoms and the Dermatology Life Quality Index. We performed a descriptive statistical analysis, chi-square test and Mann-Whitney test for categorical data, Pearson for numeric variables, and multiple regression for categorical data. RESULTS: Forty-one patients were assessed. Their mean age was 61.78 years. Venous ulcers (48.8%) were the most prevalent. Seventy-three percent of the sample perceived no impact/low impact on quality of life in the past week, and 26.8% perceived moderate/high impact. A multiple regression analysis identified the causes of lesion, pain related to the ulcers, time of onset, and severity of the depressive symptoms as the variables that had an influence on quality of life. CONCLUSIONS: The majority of the sample perceived low or no impact of the condition on the quality of the life. The variables etiology of the lesion (p<0.001), pain related to the ulcers (p=0.001), time of onset (p=0.006), and severity of the depressive symptoms (p<0.001) had an influence on the quality of life, suggesting the need for further studies with more robust designs to confirm the causal relationship between these characteristics and quality of life.

Quality of life profile and correlated factors in chronic leg ulcer patients in the mid-west of São Paulo State, Brazil

BACKGROUND: Chronic leg ulcer may have an impact on patients' quality of life. OBJECTIVES: This study aimed to identify the impact of leg ulcers on patient's quality of life using the Dermatology Life Quality Index and to define the main factors correlated with this perception. METHOD: Cross-sectional, non-probabilistic sampling study. We included patients with chronic leg ulcers being treated for at least 3 months. A sociodemographic and clinical survey was conducted to assess the profile of the ulcers. We administered a screening for depressive symptoms and the Dermatology Life Quality Index. We performed a descriptive statistical analysis, chi-square test and Mann-Whitney test for categorical data, Pearson for numeric variables, and multiple regression for categorical data. RESULTS: Forty-one patients were assessed. Their mean age was 61.78 years. Venous ulcers (48.8%) were the most prevalent. Seventy-three percent of the sample perceived no impact/low impact on quality of life in the past week, and 26.8% perceived moderate/high impact. A multiple regression analysis identified the causes of lesion, pain related to the ulcers, time of onset, and severity of the depressive symptoms as the variables that had an influence on quality of life. CONCLUSIONS: The majority of the sample perceived low or no impact of the condition on the quality of the life. The variables etiology of the lesion (p<0.001), pain related to the ulcers (p=0.001), time of onset (p=0.006), and severity of the depressive symptoms (p<0.001) had an influence on the quality of life, suggesting the need for further studies with more robust designs to confirm the causal relationship between these characteristics and quality of life. .

Implante de queratinócitos autólogos em úlceras de membros inferiores de pacientes com sequelas de hanseníase / Keratinocytes autologous implantation in lower limb ulcers of patients with leprosy sequelae

Na hanseníase as úlceras podem surgir, principalmente,pelo fato de existirem áreas anestésicas, que com facilidade podem ser traumatizadas, queimadas e secundariamente infectadas. Este estudo teve por objetivo tratar as úlceras de membro inferior de pacientes com seqüelas de hanseníase por meio do implante de queratinócitos autólogos. Participaram 14 pacientes,sendo seis com uma única úlcera, quatro com mais de uma úlcera no mesmo membro inferior e quatro com úlceras nos dois membros, totalizando 31 úlceras...

The occurrence of ulcers in leprosy is mainly due to the existence of numb areas that can easily undergo trauma and burns and there after become secondarily infected. This study aimed to treat ulcers in lower limbs of patients with leprosy sequelae through the implantation of autologous keratinocytes. The study consisted offourteen patients (six with a single ulcer, four with more than one ulcer in the same limb and four with ulcers in both limbs) with a total of 31 ulcers...